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M Cocchietto Selected Research

imidazolium- bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) (NAMI-A)

1/2015Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity.
4/2006Inhibition of B16 melanoma metastases with the ruthenium complex imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate and down-regulation of tumor cell invasion.
4/2005Free exchange across cells, and echistatin-sensitive membrane target for the metastasis inhibitor NAMI-A (imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate) on KB tumor cells.
6/2004Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A.
11/2003Biological role of adduct formation of the ruthenium(III) complex NAMI-A with serum albumin and serum transferrin.
2/2002Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A.
5/2001Tumour cell uptake G2-M accumulation and cytotoxicity of NAMI-A on TS/A adenocarcinoma cells.
1/2001Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma.
12/2000Lack of In vitro cytotoxicity, associated to increased G(2)-M cell fraction and inhibition of matrigel invasion, may predict In vivo-selective antimetastasis activity of ruthenium complexes.
11/2000Blood concentration and toxicity of the antimetastasis agent NAMI-A following repeated intravenous treatment in mice.

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M Cocchietto Research Topics

Disease

8Neoplasm Metastasis (Metastasis)
01/2015 - 11/2000
5Neoplasms (Cancer)
07/2015 - 12/2000
4Carcinoma (Carcinomatosis)
06/2004 - 01/2001
1Diabetic Nephropathies (Diabetic Nephropathy)
12/2008
1Melanoma (Melanoma, Malignant)
04/2006
1Experimental Melanoma
04/2006
1Pasteurella Infections (Pasteurellosis)
04/2005
1Adenocarcinoma
05/2001
1Lewis Lung Carcinoma
12/2000

Drug/Important Bio-Agent (IBA)

10imidazolium- bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) (NAMI-A)IBA
01/2015 - 11/2000
7RutheniumIBA
01/2015 - 11/2000
2Pharmaceutical PreparationsIBA
07/2015 - 01/2015
2Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
04/2005 - 02/2002
1Muramidase (Lysozyme)IBA
12/2008
1AlginatesIBA
12/2008
1ChitosanIBA
12/2008
1Lysine (L-Lysine)FDA Link
04/2006
1Actins (F Actin)IBA
04/2006
1Fibronectins (Fibronectin)IBA
04/2006
1GelatinasesIBA
04/2006
1echistatinIBA
04/2005
1imidazoleIBA
04/2005
1VaccinesIBA
04/2005
1TrypsinIBA
06/2004
110-hydroperoxy-7-methylnorethindrone 17-heptanoateIBA
06/2004
1Proteins (Proteins, Gene)FDA Link
11/2003
1AlbuminsIBA
11/2003
1Transferrin (beta 2 Transferrin)IBA
11/2003
1Serum AlbuminIBA
11/2003
1Glutathione (Reduced Glutathione)IBA
02/2002
1SolutionsIBA
02/2002
1Cysteine (L-Cysteine)FDA Link
02/2002
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
02/2002
1LigandsIBA
02/2002
1matrigelIBA
12/2000
1SodiumIBA
12/2000
1dichlorotetrakis(dimethyl sulfoxide)ruthenium II (trans-Ru)IBA
12/2000

Therapy/Procedure

1Microspheres (Microsphere)
12/2008